Role of conduit volume as a compensatory mechanism to left atrial dysfunction in severe aortic stenosis

Abstract Background Left atrial (LA) function has a central role in maintaining optimal cardiac output despite impaired left ventricular (LV) diastolic through reservoir, conduit and contractile functions. In normal subjects, the contribution of LA volume (conduit contractile) to LV filling is approximately 60–70% rest completed by (CV) defined as blood flow from pulmonary veins during passive emptying that does not produce change volume. As pressures progressively increase, limits preload reserve are reached serves predominantly with increase CV. Severe aortic stenosis characterized dysfunction (DD) early stages disease more advanced stages. Purpose The aim study was analyze CV compensatory mechanism complete presence dysfunction. Methods 210 patients (p) (age 69±11 years, 48% female) severe (aortic valve area index 0.37±0.12 cm2/m2) were studied Doppler echocardiography. evaluated (total) fraction (LAEF) difference between maximum (Mx) (include phases) minimum (Mn) volumes/Mx x 100 peak strain. SV estimated percentage (CV%): − (LA Mx Mn volume)/SV 100. volumes, ejection (LVEF) calculated Simpson method. Grade DD classified according ASE/EACVI recommendation p divided 3 groups: grade I (98 p), II (74 p) III (38 p). Results CV% negatively related LAEF (r=−0.57, p<0.0001) strain (r=−0.38, p<0.001) directly (r=0.35, p<0.001). LVEF correlated (r=0.57, (r=−033, group maintained significant decrease Conclusion expressed decreased an (CV%). AS, progress, Funding Acknowledgement Type funding sources: None. Table